MEK INHIBITORS: THE CHEMISTRY AND BIOLOGICAL ACTIVITY OF U0126,ITS ANALOGS, AND CYCLIZATION PRODUCTS John V. Duncia,Joseph B,et al. Bioorganic & Medicinal Chemistry Letters 1998;8:2839-2844
U0126 Reverses Ki-ras-mediated Transformation by Blocking Both Mitogen-activated Protein Kinase and p70 S6 Kinase Pathways Hidesuke Fukazawa and Yoshimasa Uehara Cancer Res 2000;60:2104-2107
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.