2 Biological Activity
NXY-059 is the disulfonyl derivative of the neuroprotective spin trap phenylbutynitrone or "PBN". Both NXY-059, its parent PBN and their hydrolysis/oxidation product MNT are very powerful scavengers of free radicals. Unlike most antioxidants, this does not involve the further production of a reactive free radical. So they are particularly effective in terminating radical chain reactions. Likewise, unlike PBN and its derivatives, most reducing antioxidants can act as pro-oxidants. [1][2]
3 References:
[1] http://en.wikipedia.org/wiki/Disufenton_sodium
[2] Shuaib A et al. N Engl J Med. 2007 Aug 9;357(6):562-71.
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.