2​ Biological Activity Evodiamine (Isoevodiamine) is an alkaloid extract from a plant known as Evodiae Fructus. The substance has been used as a weight loss supplement in Chinese medicine for centuries. It apparently works as a powerful stimulant that raises body temperature and increases metabolism while providing energy to the user. However, without proper clinical evidence to prove if this substance is effective for weight loss in humans it may be premature to consider evodiamine an effective weight loss ingredient. [1] 3​ References: The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.