Catalog Number:

E1A1459P-1,E1A1459P-2

Amount:

50ul,100ul

Reactivity:

Human

Applications:

WB, ELISA

Gene Name :

RAD50

 Gene ID :

10111

Swiss-Prot No.:

Q92878

Immunogen:

Synthesized phosho peptide around human Rad50 (Ser635)

Specificity/Sensitivity:

This antibody detects endogenous levels of Human Rad50 (phospho-Ser635)

Formulation:

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Source:

Rabbit

Dilution:

Western Blot: 1/500 - 1/2000. ELISA: 1/20000.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinitychromatography using epitope-specific immunogen.

Storage/Stability:

-20°C/1 year

Molecular weight:

153kd

Background:

RAD50 double strand break repair protein(RAD50) Homo sapiens The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.