• Catalog Number:

  E8M0407-28

• Amount:

  100ul

• Form of Antibody:

  Mouse Monoclonal IgG1 in 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol. Preservative: 0.05% Sodium Azide.

• Storage/Stability:

  Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

• Reactivity:

  Human, Mouse, Rat

• SwissProtNo:

  P49817 (mouse)

• Source:

  mouse

• Applications:

  WB: 1:500-1,000

• Specificity Sensitivity:

  This antibody is produced by immunizing mouse with a synthetic peptide (KLH-coupled) corresponding to near C-terminal residues of caveolin-1.

• References:

  1. Scherer P.E., Tang Z., et al. J. Biol. Chem. 270:16395-16401(1995) 2. Okamoto, T., et al. Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J. Biol. Chem. 273: 5419–5422 (1998) 3. Smart, E.J., et al. Caveolins, liquid-ordered domains, and signal transduction. Mol. Cell. Biol. 19: 7289–7304(1999).

Caveolin, an integral membrane protein, is a principal component of caveolae membranes in vivo. Two isoforms of caveolin have been identified: a slower migrating 24-kDa species (-isoform) and a faster migrating 21-kDa species (-isoform). Caveolins interact with multiple signaling molecules, such as the G-protein alpha subunit, tyrosine kinase receptors, PKCs, Src family tyrosine kinases and eNOS. Caveolin-1 has been implicated in the pathogenesis of mammary epithelial cell hyperplasia.