This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of CD146.
References:
1. Lehmann J.M., Riethmueller G., Johnson J.P.; "MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily."; Proc. Natl. Acad. Sci. U.S.A. 86:9891-9895(1989).
2. Sers C., Kirsch K., Rothbaecher U., Riethmueller G., Johnson J.P.; "Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains."; Proc. Natl. Acad. Sci. U.S.A. 90:8514-8518(1993).