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Catalog Number:
E1KS1594Amount:
5mgStorage/Stability:
at -20℃ 2 yearsReferences:
Semagacestat (LY450139) is a γ-secretase blocker with an IC50 of 15 nM.β-amyloid is a peptide of 39 to 43 amino acids. [1] The isoforms with 40 and 42 amino acids (Aβ40/42) are the main constituents of amyloid plaques in the brains of Alzheimer’s disease patients. β-amyloid is formed by proteolysis of APP. Research on laboratory rats suggest that the soluble form of this peptide is a causative agent in the development of Alzheimer’s. Semagacestat blocks the enzyme γ-secretase, which (along with β-secretase) is responsible for APP proteolysis. [2] The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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