![2 Biological Activity
AG 490 is a potent epidermal growth factor receptor kinase autophosphorylation inhibitor with an IC50 of 100 nM and 56.8μM for EGFR and JAK, respectively. It inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo. It selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal hematopoiesis. It inhibits the constitutive activation of STAT-3 DNA binding and IL-2-induced growth of MF tumor cells. It displays apoptotic and antiproliferative properties with IC50 of 1.7, 2.8 and 6.1 µM in 2E8, Baf/3 and Jurkat cells, respectively. [1][2]
3 References:
JAK3, STAT, and MAPK Signaling Pathways as Novel Molecular Targets for the Tyrphostin AG-490 Regulation of IL-2-Mediated T Cell Response Li Hua Wang, Robert A. Kirken,et al. J Immunol 1999;162;3897-3904
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Naftaly Meydan,Tom Grunberger et al. Nature 1996;379:645-648
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.](http://uc-hk2.njagan.com/oss/enogene-backend-image/E1KS1143/img/435.png)
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Catalog Number:
E1KS1143Amount:
25mg1 PHYSICAL AND CHEMICAL PROPERTIESStorage/Stability:
at -20℃ 2 years
2 Biological Activity AG 490 is a potent epidermal growth factor receptor kinase autophosphorylation inhibitor with an IC50 of 100 nM and 56.8μM for EGFR and JAK, respectively. It inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo. It selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal hematopoiesis. It inhibits the constitutive activation of STAT-3 DNA binding and IL-2-induced growth of MF tumor cells. It displays apoptotic and antiproliferative properties with IC50 of 1.7, 2.8 and 6.1 µM in 2E8, Baf/3 and Jurkat cells, respectively. [1][2] 3 References: JAK3, STAT, and MAPK Signaling Pathways as Novel Molecular Targets for the Tyrphostin AG-490 Regulation of IL-2-Mediated T Cell Response Li Hua Wang, Robert A. Kirken,et al. J Immunol 1999;162;3897-3904 Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Naftaly Meydan,Tom Grunberger et al. Nature 1996;379:645-648 The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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