• Catalog Number:

  E1KS1117

• Amount:

  5mg1​ PHYSICAL AND CHEMICAL PROPERTIES

• Storage/Stability:

  at -20℃ 2 years

2​ Biological Activity Triciribine is a synthetic tricyclic nucleoside which acts as a specific inhibitor of the Akt signaling pathway. It selectively inhibits the phosphorylation and activation of Akt1, -2 and -3 but does not inhibit Akt kinase activity nor known upstream Akt activators such as PI 3-Kinase and PDK1. It inhibits cell growth and induces apoptosis preferentially in cells that express aberrant Akt. This agent is shown≥ 80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p. [1,2] 3​ References: Deoxy sugar analogues of triciribine: correlation of antiviral and antiproliferative activity with intracellular phosphorylation Porcari AR, Ptak RG, et al. J Med Chem 2000 Jun 15;43(12):2438-48 An improved total synthesis of triciribine: a tricyclic nucleoside with antineoplastic and antiviral properties. Porcari AR, Townsend LB Nucleosides Nucleotides Nucleic Acids 2004;23(1-2):31-9 The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.