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Catalog Number:
E1KS1104Amount:
2mgStorage/Stability:
at -20℃ 2 yearsReferences:
Antitumor Efficacy of the Novel RAF Inhibitor GDC-0879 Is Predicted by BRAF V600E Mutational Status and Sustained Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway Suppression Sylvia Herter, Janet Tien, et al. Cancer Res 2009;69:3042-3051 Pharmacodynamics of 2-{4-[(1E)-1-(Hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1H-pyrazol-1-yl}ethan-1-ol (GDC-0879), a Potent and Selective B-Raf Kinase Inhibitor:Understanding Relationships between Systemic Concentrations,Phosphorylated Mitogen-Activated Protein Kinase Kinase 1 Inhibition, and Efficacy Harvey Wong, Marcia Belvin,et al. JPET 2009;329:360–367 The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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