PTK787/ZK 222584, a Novel and Potent Inhibitor of Vascular Impairs Endothelial Growth Factor Receptor Tyrosine Kinases,Vascular Endothelial Growth Factor-induced Responses and Tumor Growth after Oral Administration Guido Bold, Elizabeth Buchdunger, et al. Cancer Res 2000;60:2178-2189
Effects of PTK787/ZK 222584, a Specific Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, on Primary Tumor, Metastasis, Vessel Density, and Blood Flow in a Murine Renal Cell Carcinoma Model Joachim Drevs, Inga Hofmann,et al. Cancer Res 2000;60:4819-4824
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.