EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation. Trowe T et al. Clin Cancer Res. 2008 Apr 15;14(8):2465-75.
Inhibition of the T790M gatekeeper mutant of the epidermal growth factor receptor by EXEL-7647. Gendreau SB, et al. Clin Cancer Res. 2007 Jun 15;13(12):3713-23
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.