• Catalog Number:

  E1KS2675

• Amount:

  5mg1​ PHYSICAL AND CHEMICAL PROPERTIES

2​ Biological Activity D-106669 is a highly selective PI3K inhibitor with a submicromolar inhibition. It is well docume D-106669nted that the pyridopyrazine core of D-106669 is substituted by an aniline residue, and has been the base scaffold of a more advanced derivative AEZS-126 which is also identified as a selective class I PI3K inhibitor with an IC50 of < 10nM for PI3K alpha. When was given at oral dose of 30mg/kg twice daily, D-106669 presented certain inhibitory activity in A549 xenografts mouse model. Another optimized compound of NVP-BEZ235 is NVP-BEZ235 that is also a PI3K alpha inhibitor (IC50 =4nM) but has less suppressed PI3Kγ, β and δ. [1] 3​ References: The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.