![2 Biological Activity
URB597 is a relatively selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 4.6 and 0.5 nM in brain membranes and intact neurons, respectively. FAAH is the primary degradatory enzyme for the endocannabinoid anandamide and, as such, inhibition of FAAH leads to an accumulation of anandamide in the CNS and periphery where it activates cannabinoid receptors. URB597 produced measurable antidepressant and analgesic effects by increasing endocannabinoids. URB597 shows both anti-nociceptive and anxiolytic effects in vivo but not evokes other symptoms associated with cannabinoid-like compounds. Hence, URB597 may provide a new strategy for the treatment of pain and anxiety. [1][2]
3 References:
http://en.wikipedia.org/wiki/URB597 http://en.wikipedia.org/wiki/URB597 ;
http://www.ncbi.nlm.nih.gov/pubmed/11470906 Cravatt BF et al. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9371-6.
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.](http://uc-hk2.njagan.com/oss/enogene-backend-image/E1KS2631/img/4db.png)
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E1KS2631Amount:
5mg1 PHYSICAL AND CHEMICAL PROPERTIES
2 Biological Activity URB597 is a relatively selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 4.6 and 0.5 nM in brain membranes and intact neurons, respectively. FAAH is the primary degradatory enzyme for the endocannabinoid anandamide and, as such, inhibition of FAAH leads to an accumulation of anandamide in the CNS and periphery where it activates cannabinoid receptors. URB597 produced measurable antidepressant and analgesic effects by increasing endocannabinoids. URB597 shows both anti-nociceptive and anxiolytic effects in vivo but not evokes other symptoms associated with cannabinoid-like compounds. Hence, URB597 may provide a new strategy for the treatment of pain and anxiety. [1][2] 3 References: http://en.wikipedia.org/wiki/URB597 http://en.wikipedia.org/wiki/URB597 ; http://www.ncbi.nlm.nih.gov/pubmed/11470906 Cravatt BF et al. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9371-6. The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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