![2 Biological Activity
GW3965 HCl is a synthetic selective, active non-steroidal liver X receptor (LXR) agonist with EC50 of 0.19 and 0.03 μM for hLXRα and hLXRβ, respectively. Angiotensin II-mediated increases in blood pressure can be reduced by GW3965 HCl . In HepG2 cells, the EC50 for GW3965 is greater than 4 μM. In an animal study, GW3965 HCl decreased lesion area by 53% 34% in male and female LDLR-/- mice, respectively. GW3695 induced expression of ATP-binding cassettes A1 and G1 in modified low-density lipoprotein-loaded macrophages in vitro as well as in the aortas of hyperlipidemic mice. Additionally, GW3965 HCl increases ABCA1 gene expression and raises circulating HDL levels. GW3965 HCl displays potent antiatherogenic activity in mouse models of atherosclerosis. [1][2]
3 References:
http://www.ncbi.nlm.nih.gov/pubmed/17420776 Leik CE et al. Br J Pharmacol. 2007 Jun;151(4):450-6.
http://www.ncbi.nlm.nih.gov/pubmed/15145986 Miao B et al. J Lipid Res. 2004 Aug;45(8):1410-7.
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.](http://uc-hk2.njagan.com/oss/enogene-backend-image/E1KS2630/img/4db.png)
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5mg1 PHYSICAL AND CHEMICAL PROPERTIES
2 Biological Activity GW3965 HCl is a synthetic selective, active non-steroidal liver X receptor (LXR) agonist with EC50 of 0.19 and 0.03 μM for hLXRα and hLXRβ, respectively. Angiotensin II-mediated increases in blood pressure can be reduced by GW3965 HCl . In HepG2 cells, the EC50 for GW3965 is greater than 4 μM. In an animal study, GW3965 HCl decreased lesion area by 53% 34% in male and female LDLR-/- mice, respectively. GW3695 induced expression of ATP-binding cassettes A1 and G1 in modified low-density lipoprotein-loaded macrophages in vitro as well as in the aortas of hyperlipidemic mice. Additionally, GW3965 HCl increases ABCA1 gene expression and raises circulating HDL levels. GW3965 HCl displays potent antiatherogenic activity in mouse models of atherosclerosis. [1][2] 3 References: http://www.ncbi.nlm.nih.gov/pubmed/17420776 Leik CE et al. Br J Pharmacol. 2007 Jun;151(4):450-6. http://www.ncbi.nlm.nih.gov/pubmed/15145986 Miao B et al. J Lipid Res. 2004 Aug;45(8):1410-7. The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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