![2 Biological Activity
PNU-120596 is a potent and selective positive allosteric α7 neuronal nicotinic acetylcholine receptors modulator with an EC50 of 0.2 μM. PNU-120596 has no detectable effect on α4β2, α3β4 and α9α10 receptors. Discovered in a high-throughput screen, PNU-120596 enhanced agonist-evoked calcium flux mediated by an engineered variant of the human α7 nAChR. Electrophysiology studies demonstrated that PNU-120596 increased peak agonist-evoked currents mediated by wild-type receptors and also proved a pronounced prolongation of the triggered response in the continued presence of agonist. [1][2]
3 References:
http://en.wikipedia.org/wiki/PNU-120,596 http://en.wikipedia.org/wiki/PNU-120,596 ;
A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. Hurst RS et al. J Neurosci. 2005 Apr 27;25(17):4396-405.
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.](http://uc-hk2.njagan.com/oss/enogene-backend-image/E1KS2629/img/4db.png)
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Catalog Number:
E1KS2629Amount:
10mg1 PHYSICAL AND CHEMICAL PROPERTIES
2 Biological Activity PNU-120596 is a potent and selective positive allosteric α7 neuronal nicotinic acetylcholine receptors modulator with an EC50 of 0.2 μM. PNU-120596 has no detectable effect on α4β2, α3β4 and α9α10 receptors. Discovered in a high-throughput screen, PNU-120596 enhanced agonist-evoked calcium flux mediated by an engineered variant of the human α7 nAChR. Electrophysiology studies demonstrated that PNU-120596 increased peak agonist-evoked currents mediated by wild-type receptors and also proved a pronounced prolongation of the triggered response in the continued presence of agonist. [1][2] 3 References: http://en.wikipedia.org/wiki/PNU-120,596 http://en.wikipedia.org/wiki/PNU-120,596 ; A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. Hurst RS et al. J Neurosci. 2005 Apr 27;25(17):4396-405. The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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