• Catalog Number:

  E1KS2618

• Amount:

  2mg1​ PHYSICAL AND CHEMICAL PROPERTIES

2​ Biological Activity LDN193189 is a highly potent small molecule BMP inhibitor with IC50 of 5 and 30 nM for ALK2 and ALK3, respectively. LDN193189 also inhibits BMP type I receptors ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation. LDN193189 inhibits FOP and ectopic ossification and a potential agent in the treatment of NSCLC lung tumors. LDN193189 affects not only the Smad but also the non-Smad signalling pathways induced by either BMP2, BMP6 or GDF5. The activation of p38, ERK1/2 and Akt in C2C12 cells was inhibited by LDN193189.[1][2] 3​ References: The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.