USP6NL; KIAA0019; USP6 N-terminal-like protein; Related to the N-terminus of tre; Background:Acts as a GTPase-activating protein for RAB5A. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 Rab-GAP TBC domain.,subunit:Interacts with EPS8.,tissue specificity:Widely expressed.
Specificity Sensitivity:
RN-tre Polyclonal Antibody detects endogenous levels of RN-tre protein.
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma using USP6NL Antibody. The picture on the right is blocked with the synthesized peptide.