• Catalog Number:

  E1A8404A-3

• Amount:

  100ul

• Form of Antibody:

  Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Storage/Stability:

  Store at -20℃/1 year

• class="eg_cn_title"Immunogen:

  The antiserum was produced against synthesized phosphopeptide derived from human PSEN1 around the phosphorylation site of serine 357 (P-E-SP-R-A).

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

• Reactivity:

  Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%);Rat (Identities = 100%, Positives = 100%)

• SwissProtNo:

  P49768

• Applications:

  WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:5000

• Other Names:

  AD3; AD3H; EC 3.4.23.-; presenilin 1; PS-1; PS1; PSN1; PSNL1; S182 protein

• Specificity Sensitivity:

  PSEN1 (Phospho-Ser357) antibody detects endogenous levels of PSEN1 only when phosphorylated at serine 357.

• References:

  Sherrington R., Nature 375:754-760(1995). Sahara N., FEBS Lett. 381:7-11(1996). Heilig R., Nature 421:601-607(2003).

• All Sites:

  Human: Ser357; Mouse: Ser357; Rat: Ser358

P-peptide - +

Immunohistochemistry analysis of paraffin-embedded human brain tissue using PSEN1 (Phospho-Ser357) antibody. Western blot analysis of extracts from RAW264.7 cells, treated with UV (5mins), using PSEN1 (Phospho-Ser357) antibody.