• Catalog Number:

  E1A0028A-2

• Amount:

  50ul

• Form of Antibody:

  Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Storage/Stability:

  Store at -20℃/1 year

• class="eg_cn_title"Immunogen:

  The antiserum was produced against synthesized phosphopeptide derived from human SHP-2 around the phosphorylation site of tyrosine 580 (R-V-YP-E-N).

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

• Reactivity:

  Human, Mouse, Rat

• SwissProtNo:

  Q06124

• Applications:

  WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000

• Alter Name:

  EC 3.1.3.48, PTN11, PTP-1D, PTP-2C, PTP2C, PTPN11, Protein-tyrosine phosphatase 2C, Protein-tyrosine phosphatase, non-receptor type 11, SH-PTP2, SH-PTP3, SHPTP2

• Specificity Sensitivity:

  SHP-2(phospho-Tyr580) antibody detects endogenous levels of SHP-2 only when phosphorylated at tyrosine 580.

• References:

  Minako Yamaoka-Tojo, Arterioscler. Thromb. Vasc. Biol., Sep 2006; 26: 1991 - 1997. Liang Liang, Endocrinology, Sep 2000; 141: 3328. Tony Avril, J. Immunol., Dec 2004; 173: 6841 - 6849. Laura A. Maile, Mol. Biol. Cell, Sep 2003; 14: 3519.

• All Sites:

  Human: Tyr580; Mouse: Tyr584; Rat: Tyr580

P-peptide - + Immunohistochemical analysis of paraffin-embedded human brain tissue using SHP-2 (phospho-Tyr580) antibody.

Western blot analysis of extracts from A431cells, using SHP-2 (phospho-Tyr580) antibody.